Publications
ResearcherID : C-5956-2008 (TY, h-index: 24) , AAZ-8749-2021 (RK, h-index: 11)
Google Scholar : TY (h-index: 34), RK (h-index: 11)
2023
Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Ryuji Igarashi, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata
Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles Journal Article
In: AIP Advances, vol. 13, pp. 025144, 2023.
Abstract | Links | BibTeX | Tags: Virus Detection
@article{virusNPs,
title = {Rapid virus detection using magnetic second harmonics of superparamagnetic iron oxide nanoparticles},
author = {Ryuichi Hirota and Toru Murayama and Ryota Katsumi and Tokuhisa Kawawaki and Shin Yabukami and Ryuji Igarashi and Yuichi Negishi and Moriaki Kusakabe and Masaki Sekino and Takashi Yatsui and Akihiro Kuwahata},
doi = {10.1063/9.0000483},
year = {2023},
date = {2023-02-09},
urldate = {2023-02-09},
journal = {AIP Advances},
volume = {13},
pages = {025144},
abstract = {Virus detection methods based on nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic are widely applied, owing to their high sensitivity and short measurement time. This paper proposes a virus detection method based on the second harmonic because of its larger signal component. We found that the second harmonic signal is superior to the third harmonic signal for small nanobeads and a large change of the second harmonic signal in the signal-to-noise ratio (SNR) with nanobeads concentration. In addition, a virus detection limit of 100 pg/ml is achieved. Therefore, the proposed method can potentially be utilized for rapid screening of viruses.},
keywords = {Virus Detection},
pubstate = {published},
tppubtype = {article}
}
Virus detection methods based on nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic are widely applied, owing to their high sensitivity and short measurement time. This paper proposes a virus detection method based on the second harmonic because of its larger signal component. We found that the second harmonic signal is superior to the third harmonic signal for small nanobeads and a large change of the second harmonic signal in the signal-to-noise ratio (SNR) with nanobeads concentration. In addition, a virus detection limit of 100 pg/ml is achieved. Therefore, the proposed method can potentially be utilized for rapid screening of viruses.
2022
Ryuichi Hirota, Toru Murayama, Ryota Katsumi, Tokuhisa Kawawaki, Shin Yabukami, Ryuji Igarashi, Yuichi Negishi, Moriaki Kusakabe, Masaki Sekino, Takashi Yatsui, Akihiro Kuwahata
Virus Detection using Second Harmonics of Magnetic Nanoparticles Journal Article
In: IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING, vol. 17, iss. 8, pp. 1228-1230, 2022.
Abstract | Links | BibTeX | Tags: SHG, Virus Detection
@article{SHvirus,
title = {Virus Detection using Second Harmonics of Magnetic Nanoparticles},
author = {Ryuichi Hirota and Toru Murayama and Ryota Katsumi and Tokuhisa Kawawaki and Shin Yabukami and Ryuji Igarashi and Yuichi Negishi and Moriaki Kusakabe and Masaki Sekino and Takashi Yatsui and Akihiro Kuwahata},
doi = {10.1002/tee.23613},
year = {2022},
date = {2022-04-12},
urldate = {2022-04-12},
journal = {IEEJ TRANSACTIONS ON ELECTRICAL AND ELECTRONIC ENGINEERING},
volume = {17},
issue = {8},
pages = {1228-1230},
abstract = {Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R24) and the ratio of the third harmonic to the fifth harmonic (R35) shows that R24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.},
keywords = {SHG, Virus Detection},
pubstate = {published},
tppubtype = {article}
}
Virus detection methods based on the nonlinear magnetic response of magnetic nanoparticles have been investigated, and magnetic detection methods using the third harmonic have been widely applied on account of their high sensitivity, short measurement-time, and low cost. In this letter, we propose a virus detection method using the second harmonics to improve the signal intensity. We find that the signal to noise ratio of the second harmonic is approximately three times higher than that of the third harmonic. A comparison of the ratio of the second harmonic to the fourth harmonic (R24) and the ratio of the third harmonic to the fifth harmonic (R35) shows that R24 is more sensitive to identifying changes in virus concentration. Our proposed method has the potential to be utilized for rapid screening on virus detection.